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NIH Paper Submissions

Information on NIH Paper Submissions.

Although the NIH has multiple electronic submission options, sub-award applications and a few non-standard applications still require paper applications to be submitted.

For new, renewal, resubmission, and supplement applications, the department should use the PHS 398 forms. For continuations (progress reports), the department should use the PHS 2590 forms.  The Sponsored Projects Office (SPO) has pre-populated Face Pages for both form types on our Resources page. Note, that the SF424 Subaward Budget Form (interactive)  is the preferred form for the budget. You would upload the budget justification on page 3 of the first year of this form. Do not print this as a PDF, but keep it interactive.

Please see the Subaward Review Priorities which outlines both the department's and the SPO's responsibilities in reviewing PHS forms. 

Please be aware that SPO's minimum requirements are in effect even if the agency does not require these documents or only requires some of them. The SPO cannot process a sub-award without our minimum requirements.

PHS Forms Walk-Thru

The Sponsored Projects Office (SPO) has prepared the following guides for the PHS 398 and PHS 2590 forms. Please see the attached documents with highlights and notes with instructions on how to fill in the forms. 

Submission to the SPO

To submit your sub-award application to the SPO for review and/or submission, please follow the instructions for PD. The SPO requests that the sub-award package be combined into ONE (1) PDF rather than uploaded as individual attachments for ease of use. However, if an SF424 Subaward Budget is included, please have this be a separate upload since the form is interactive. Do not print this to PDF to flatten.


For additional guidance, please refer to the PHS application guides: 

For more information or questions email