Regulated biological materials covered in UC San Diego's Biosafety Program include:
- Biological toxins
- Infectious organisms that can cause disease in humans or cause significant environmental or agricultural impact
- Human or primate tissues, fluids, cells, or cell cultures
- Animal tissues, fluids, cells, or cell cultures that have been exposed to infectious organisms
- Recombinant DNA in vitro, in vivo, and in clinical trials
- Transgenic plants or animals
- Human gene transfer clinical trials
- Releases of recombinant DNA to the environment
- Animals known to be reservoirs of zoonotic diseases
- Select Agents
Principal investigators must have an approved Biohazard Use Authorization (BUA) before beginning work with UCSD regulated biological materials (see the list above). The BUA is an application for use of most biological material; it lists more than just biohazardous materials.
Eligible PIs must have assigned laboratory space as determined by the university.
- See Apply For and Manage a BUA for details, including requirements for applications involving human gene transfer clinical trials (gene therapy).
Important: The PI is ultimately responsible for full compliance with policies, practices, and procedures set by the UCSD Institutional Biosafety Committee when a Biohazard Use Authorization is granted. The UCSD Biosafety Handbook (PDF) is the primary reference for compliance with these requirements.
Responsibility extends to all aspects of biosafety involving individuals who enter or work in the laboratory or under the auspices of the PI.
Note: Other research authorizations to work with regulated materials or human or animal subjects at UCSD may be required.
The UCSD Biosafety Handbook
(PDF) is the primary reference for practices, procedures, facility construction, and operational standards required for safe handling and use of biohazardous materials for research, clinical, and teaching activities at UC San Diego.
The Institutional Biosafety Committee (IBC) oversees use of biohazard materials by:
- Creating and enforcing policies and procedures
- Reviewing the use of biohazard materials
- Monitoring construction and use of biohazard containment facilities
IBC activities are guided by university policy, national guidelines, industry standards, and federal, state, and county regulations. The IBC reviews and approves all projects that involve biohazard materials before work begins.
Submission dates: BUA applications are reviewed at the IBC's monthly meeting. See the IBC Important Dates schedules (PDF) for due dates:
Read about My Research Safety, a Web portal for centralized access to your Environment, Health & Safety (EH&S) audits, inventory, and authorizations.
Government and research institutions:
- American Biological Safety Association (ABSA) - professional association that publishes and distributes a quarterly journal, "Applied Biosafety," and a number of other biosafety publications
- American Journal of Bioethics, Bioethics.net - moral issues in the fields of medical treatment and research, University of Pennsylvania School of Medicine
- Center for Bioethics, University of Pennsylvania
- Center for Infectious Disease Research And Policy, University of Minnesota - general bioterrorism information
- Medical Matrix - a project of the American Medical Association's Internet Working Group
- MEDLINEplus - health topics, drug information, medical encyclopedia, dictionary, and other resources
- Medscape from WebMD - peer-reviewed articles, color graphics, stored literature searches, and annotated links to Internet resources
- Morbidity & Mortality Weekly Reports, Centers for Disease Control and Prevention
- Multimedia Medical Reference Library - medical information resources for medical professionals, students, and patients
- National Health Information Center - toll-free information numbers, federal clearinghouses, and other resources
- National Institutes of Health Library - health information, scientific journals, and books
- National Library of Medicine - world's largest medical library
- OncoLink, University of Pennsylvania - information about specific types of cancer, updates on cancer treatments, and news about research advances
- PubMed - references and abstracts from more than 4,500 biomedical journals, National Library of Medicine
- UCSD Biomedical and Medical Center Libraries