| Checklist |
What to do |
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Follow all appropriate procedures. |
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Obtain required approvals before beginning work. |
- Request prior approval and obtain a risk assessment from the Animal Subjects Committee, (858) 534-6069, by submitting an online protocol.
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Consult before beginning work. |
- Contact the chemical safety officer, (858) 822-1579, before beginning work with this protocol to ensure safe use of the chemical agent.
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If protocol review indicates an unusual or unique risk to researchers or animal care staff, a safety considerations meeting will be required prior to acquiring animals.
- Safety considerations meetings include all individuals (research staff, animal care personnel, and Environment, Health & Safety) that have a vested interest in ensuring the safe use of the particular chemical agent.
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Follow these training guidelines. |
A principal investigator (PI) or knowledgeable designee must provide appropriate safety training.
- Inform employees about handling the drug or chemical, its physical properties (including solubility), and health effects seen in experimental studies and other applicable sources.
- Review toxicological data from similar compounds if toxicological information is limited.
- Explain possible routes of exposure as appropriate:
- Inhalation
- Skin absorption
- Accidental injection
- Provide and train employees in the proper use of personal protective equipment and engineering controls to prevent exposure.
- Call (858) 534-1086 to provide the Animal Care staff with a summary of the training information.
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Label containers and cages. |
- Label all containers with the following information:
- Name of the material
- Concentration
- Warnings
- Protective measures/li>
- Date, when appropriate
- Preparer's initials, when appropriate
- Label animal cages with the appropriate hazard communication information below for the first 48 hours following administration of dosing solutions:
- "Caution: Hazardous Chemical/ Drug"
Maintain the signage following this initial period according to this criteria:
- Aqueous dosing solutions – Once the bedding has been changed, the warning sign can be removed.
- Oil-soluble dosing solutions – Maintain the signage for 96 hours.
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Take these safety precautions when administering the substance. |
- Injection or gavage: Use syringes and intravenous sets with Luer-lock fittings if possible when material is given via injection or gavage.
- Perform priming into a sterile, alcohol-dampened gauze sponge.
- Do not prime sets or syringes into the sink or any open receptacle.
- House all affected animals in micro-isolator cages.
- Diet: Use a closed-caging system if the substance must be administered in the diet. Mix all diets containing the hazardous material in closed containers inside a chemical fume hood or Class II Type B2 biosafety cabinet.
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Dispose of hazardous waste properly. |
Animal bedding, waste, and water — in addition to waste chemicals — may be subject to hazardous waste disposal requirements.
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